2026

Geva NG*, Jefferson* SJ, Krishnamurthy E, Anderson TL, Rondeau J, Wehrle PH, Rosado AF, Pittenger C, Krystal JH, Kaye AP. MDMA enhances prefrontal plasticity and representational drift during fear extinction [preprint, 2026] Available at: https://www.biorxiv.org/content/10.64898/2026.03.06.710094v1

Floris* G, Jefferson* SJ, Rondeau J, Menniti FS, Kwan AC, De Aquino JP, Krystal JH, Pittenger C, Kaye AP. Enhancing cGMP signaling with psilocybin reduces head twitch and restructures the synaptic proteome while maintaining antidepressant response [preprint, 2026] Available at: https://www.biorxiv.org/content/10.64898/2026.03.06.710108v1

2025

Aboharb F, Davoudian PA, Shao L, Liao C, Rzepka GN, Wojtasiewicz C, Indajang J, Dibbs M, Rondeau J, Sherwood A, Kaye AP, Kwan AC. Classification of psychedelics and psychoactive drugs based on brain-wide imaging of cellular c-Fos expression. Nature Communications (2025). https://www.nature.com/articles/s41467-025-56850-6

Wang H, Ortega HK, Kelly, EB, Indajang J, Savalia NK, Glaeser-Khan S, Feng J, Li Y, Kaye AP, Kwan AC. Frontal noradrenergic and cholinergic transients exhibit distinct spatiotemporal dynamics during competitive decision-making. Scientific Advances (2025). https://www.science.org/doi/full/10.1126/sciadv.adr9916

2024

Basu A, Yang JH, Yu AL, Glaeser-Khan S, Rondeau J, Feng J, Krystal JH, Li YL, Kaye AP. Frontal norepinephrine represents a threat prediction error under uncertainty. Biological Psychiatry (2024); https://www.sciencedirect.com/science/article/pii/S000632232400074X

Glaeser-Khan* S, Savalia* NK, Cressy J, Feng J, Li Y, Kwan AC, Kaye AP. Spatiotemporal Organization of Prefrontal Norepinephrine Influences Neuronal Activity. eNeuro (2024); https://www.eneuro.org/content/11/5/ENEURO.0252-23.2024

Lamsam, L, Gu, B, Liang M, Sun G, Khan KJ, Sheth KN, Hirsch LJ, Pittenger C, Kaye AP, Krystal JH, Damisah EC. The human claustrum tracks slow waves during sleep. Nature Communications 15, 8964 (2024). https://www.nature.com/articles/s41467-024-53477-x

2023

Jefferson SJ, Gregg I, Dibbs M, Liao C, Wu H, Davoudian PA, Woodburn SC, Wehrle PH, Sprouse JS, Sherwood AM, Kaye AP, Pittenger C, Kwan AC. 5-MeO-DMT modifies innate behaviors and promotes structural neural plasticity in mice. Neuropsychopharmacology (2023); https://www.nature.com/articles/s41386-023-01572-w

Yang JH, Basu A, Liu RJ, Staszko SM, Yu AL, Rondeau J, Glaeser-Khan S, Feng J, Li Y, Che A, Kaye AP. Frontal cortex norepinephrine, serotonin, and dopamine dynamics in an innate fear-reward behavioral model [preprint, 2023] Available at: https://www.biorxiv.org/content/10.1101/2023.11.27.568929v1.abstract

Kaye AP, Kwan AC, Ressler KJ, Krystal JH. A computational model for learning from repeated traumatic experiences under uncertainty. Cognitive, Affective, and Behavioral Neuroscience (2023); https://link.springer.com/article/10.3758/s13415-023-01085-5

Krystal JH, Kaye AP, Jefferson S, Girgenti MJ, Wilkinson ST, Sanacora G, & Esterlis I,  Ketamine and the neurobiology of depression: Toward next-generation rapid-acting antidepressant treatments, PNAS. U.S.A. 120 (49) e2305772120, (2023). https://www.pnas.org/doi/abs/10.1073/pnas.2305772120

2021

Kelmendi B, Kaye AP, Pittenger C, Kwan AC. Primer: Psychedelics. Current Biology (2021).

Kaye AP. Amygdala-Insula Circuit Computations in Posttraumatic Stress Disorder. Biological Psychiatry (2021).

2020

Kaye AP** and Krystal JH. Predictive coding in mental illness: hierarchical circuitry for perception and trauma. Journal of Abnormal Psychology (2020) **Corresponding author.  

2019

Chen AT, Abdallah SB, Dwyer JB, Kaye AP, Angarita GA, Bloch MH. Severe Illness Anxiety Treated by Integrating Inpatient Psychotherapy with Medical Care and Minimizing Reassurance. Frontiers in Psychiatry (2019); doi: 10.3389/fpsyt.2019.00150

2017

Kaye, AP**, Ross DA. Predicting PTSD: From Circuits to Communities. Biological Psychiatry (2017). **Corresponding author. 
Kaye, AP, and Ross, DA. The Habenula: Darkness, Disappointment, and Depression. Biological Psychiatry (2017).

2012

*Marshel J, *Kaye AP, Nauhaus I, Callaway E. Anterior-Posterior Direction Opponency in the Superficial Mouse Lateral Geniculate Nucleus. Neuron (2012) * Equal contributing authors.